Longitudinal neutralization activities on authentic Omicron variant provided by three doses of BBIBP‐CorV vaccination during one year

中和 接种疫苗 病毒学 效价 生物 疫苗效力 病毒 生物化学
作者
Dan-yun Lai,Jun‐biao Xue,Ping He,He‐wei Jiang,Yang Li,Ming-liang Ma,Wei Hong,Jun‐ping Yu,Hong‐ping Wei,Sheng-Ce Tao
出处
期刊:Proteomics [Wiley]
卷期号:: 2200306-2200306
标识
DOI:10.1002/pmic.202200306
摘要

The majority of people in China have been immunized with the inactivated viral vaccine BBIBP-CorV. The emergence of the Omicron variant raised the concerns about protection efficacy of the inactivated viral vaccine in China. However, longitudinal neutralization data describing protection efficacy against Omicron variant is still lacking. Here we present one-year longitudinal neutralization data of BBIBP-CorV on authentic Omicron, Delta, and wild-type strains using 224 sera collected from 14 volunteers who have finished three doses BBIBP-CorV. The sera were also subjected for monitoring the SARS-CoV-2 specific IgG, IgA, and IgM responses on protein and peptide microarrays. The neutralization titers showed different protection efficacies against the three strains. By incorporating IgG and IgA signals of proteins and Spike protein derived peptide on microarray, panels as potential surrogate biomarkers for rapid estimation of neutralization titers were established. These data support the necessity of the 3rd dose of BBIBP-CorV vaccination. After further validation and assay development, the panels could be used for reliable, convenient and fast evaluation of the efficacy of vaccination.
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