纳米载体
肿瘤微环境
内化
药物输送
癌细胞
药理学
内吞作用
癌症
纳米医学
联合疗法
癌症研究
化学
药品
医学
纳米技术
细胞
材料科学
生物化学
纳米颗粒
内科学
作者
Mohammad Arad Zandieh,Melika Heydari Farahani,Mahshid Daryab,Alireza Motahari,Sarah Gholami,Farshid Salmani,Fatemeh Karimi,Seyedeh Setareh Samaei,Abbas Rezaee,Parham Rahmanian,Ramin Khorrami,Shokooh Salimimoghadam,Noushin Nabavi,Rongjun Zou,Gautam Sethi,Mohsen Rashidi,Kiavash Hushmandi
标识
DOI:10.1016/j.biopha.2023.115283
摘要
The use of phytochemicals for purpose of cancer therapy has been accelerated due to resistance of tumor cells to conventional chemotherapy drugs and therefore, monotherapy does not cause significant improvement in the prognosis and survival of patients. Therefore, administration of natural products alone or in combination with chemotherapy drugs due to various mechanisms of action has been suggested. However, cancer therapy using phytochemicals requires more attention because of poor bioavailability of compounds and lack of specific accumulation at tumor site. Hence, nanocarriers for specific delivery of phytochemicals in tumor therapy has been suggested. The pharmacokinetic profile of natural products and their therapeutic indices can be improved. The nanocarriers can improve potential of natural products in crossing over BBB and also, promote internalization in cancer cells through endocytosis. Moreover, (nano)platforms can deliver both natural and synthetic anti-cancer drugs in combination cancer therapy. The surface functionalization of nanostructures with ligands improves ability in internalization in tumor cells and improving cytotoxicity of natural compounds. Interestingly, stimuli-responsive nanostructures that respond to endogenous and exogenous stimuli have been employed for delivery of natural compounds in cancer therapy. The decrease in pH in tumor microenvironment causes degradation of bonds in nanostructures to release cargo and when changes in GSH levels occur, it also mediates drug release from nanocarriers. Moreover, enzymes in the tumor microenvironment such as MMP-2 can mediate drug release from nanocarriers and more progresses in targeted drug delivery obtained by application of nanoparticles that are responsive to exogenous stimulus including light.
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