GPX4
冲程(发动机)
坏死性下垂
脂质过氧化
机制(生物学)
自噬
程序性细胞死亡
医学
细胞凋亡
细胞生物学
神经科学
癌症研究
生物
氧化应激
生物化学
内科学
哲学
工程类
谷胱甘肽过氧化物酶
过氧化氢酶
认识论
机械工程
作者
Chengli Liu,Guijun Wang,Wenrui Han,Qi Tian,Mingchang Li
标识
DOI:10.4103/1673-5374.385284
摘要
Abstract Ferroptosis is a form of regulated cell death characterized by massive iron accumulation and iron-dependent lipid peroxidation, differing from apoptosis, necroptosis, and autophagy in several aspects. Ferroptosis is regarded as a critical mechanism of a series of pathophysiological reactions after stroke because of iron overload caused by hemoglobin degradation and iron metabolism imbalance. In this review, we discuss ferroptosis-related metabolisms, important molecules directly or indirectly targeting iron metabolism and lipid peroxidation, and transcriptional regulation of ferroptosis, revealing the role of ferroptosis in the progression of stroke. We present updated progress in the intervention of ferroptosis as therapeutic strategies for stroke in vivo and in vitro and summarize the effects of ferroptosis inhibitors on stroke. Our review facilitates further understanding of ferroptosis pathogenesis in stroke, proposes new targets for the treatment of stroke, and suggests that more efforts should be made to investigate the mechanism of ferroptosis in stroke.
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