布朗运动
布朗动力学
惯性
DNA
纳米技术
物理
化学物理
纳米器件
统计物理学
材料科学
经典力学
化学
量子力学
生物化学
作者
Ignacio Madrid,Zhiyong Zheng,Cédric Gerbelot,Akira Fujiwara,Shuo Li,Simon Grall,Katsuhiko Nishiguchi,Soo Hyeon Kim,Arnaud Chovin,Christophe Demaille,Clément Nicolas
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-08-24
被引量:1
标识
DOI:10.1021/acsnano.3c04349
摘要
Theoretical treatments of polymer dynamics in liquid generally start with the basic assumption that motion at the smallest scale is heavily overdamped; therefore, inertia can be neglected. We report on the Brownian motion of tethered DNA under nanoconfinement, which was analyzed by molecular dynamics simulation and nanoelectrochemistry-based single-electron shuttle experiments. Our results show a transition into the ballistic Brownian motion regime for short DNA in sub-5 nm gaps, with quality coefficients as high as 2 for double-stranded DNA, an effect mainly attributed to a drastic increase in stiffness. The possibility for DNA to enter the underdamped regime could have profound implications on our understanding of the energetics of biomolecular engines such as the replication machinery, which operates in nanocavities that are a few nanometers wide.
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