上睑下垂
癌症研究
免疫原性细胞死亡
程序性细胞死亡
材料科学
纳米片
肿瘤微环境
体内
免疫系统
细胞凋亡
细胞生物学
免疫疗法
生物
免疫学
纳米技术
生物化学
生物技术
作者
Yunxiu Zhang,Qingyan Jia,Jian Li,Jian Wang,Ke Liang,Xiaokuang Xue,Tiejin Chen,Lingqi Kong,Haohui Ren,Weimin Liu,Pengfei Wang,Jiechao Ge
标识
DOI:10.1002/adma.202305073
摘要
Pyroptosis is increasingly considered a new weathervane in cancer immune therapy. However, triggering specific pyroptotic tumor cell death while preserving normal cells still remains a major challenge. Herein, a brand-new pyroptosis inducer, copper-bacteriochlorin nanosheet (Cu-TBB), is designed. The synthesized Cu-TBB can be activated to an "on" state in the tumor microenvironment with glutathione (GSH) overexpression, leading to the release of Cu+ and TBB, respectively. Intriguingly, the released Cu+ can drive cascade reactions to produce O2-• and highly toxic ·OH in cells. Additionally, the released TBB can also generate O2-• and 1 O2 upon 750 nm laser irradiation. Encouragingly, both Cu+ -driven cascade reactions and photodynamic therapy pathways result in potent pyroptosis along with dendritic cell maturation and T cell priming, thus simultaneously eliminating the primary tumors and inhibiting the distant tumor growth and metastases. Conclusively, the well-designed Cu-TBB nanosheet is shown to trigger specific pyroptosis in vitro and in vivo, leading to enhanced tumor immunogenicity and antitumor efficacy while minimizing systemic side effects.
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