化学
基因敲除
细胞生物学
氨基酸
新陈代谢
抄写(语言学)
转录因子
生物化学
反转运蛋白
蛋白质亚单位
铜
信号转导
基因表达
氧化磷酸化
氧化应激
癌细胞
谷氨酸受体
染色体易位
半胺
NF-κB
癌症研究
丝氨酸
基因表达调控
信使核糖核酸
作者
Tetsuro Kamiya,Ryoka Teruya,Haruka Tahara,Yuki Inoue,Aoi Ikeda,Sayaka Hosowari,Tomo Arioka,Tomohiro Otsuka,Hirokazu Hara
标识
DOI:10.1080/10715762.2025.2560847
摘要
, the nuclear translocation of Nrf2 was observed, and knockdown of Nrf2 significantly suppressed the induction of SLC7A11. Given that the Cu chaperone, antioxidant-1 (Atox1), functions as a Cu-dependent transcription factor, the role of Atox1 in the expression of SLC7A11 was further investigated. Like the effects of Nrf2 knockdown, Atox1 was found to play a pivotal role in the Cu-mediated induction of SLC7A11. Our findings indicate that intratumoral Cu influences the expression of SLC7A11 and may play a role in tumor progression.
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