Teresa Carolliny Moreira Lustoza Rodrigues,Jéssica Paiva de Moura,Aline Matilde Ferreira dos Santos,Alex France M Monteiroa,Simone Mendes Lopes,Marcus T. Scotti,Marcus Tullius Scotti
出处
期刊:Current Drug Targets [Bentham Science] 日期:2023-02-01卷期号:24 (3): 212-224被引量:1
Background: Epilepsy is a neurological disease affected by an imbalance of inhibitory and excitatory signaling in the brain. Introduction: In this disease, the targets are active in pathophysiology and thus can be used as a focus for pharmacological treatment. Methods: Several studies demonstrated the antiepileptic effect of drugs acting on the following tar-gets: N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, voltage-gated calcium channel (Cav), Gamma aminobutyric acid transporter type 1 (GAT1), voltage-gated sodium channels (Nav), voltage-gated potassium channel of the Q subfam-ily (KCNQ) and Gamma aminobutyric acid type A (GABAA) receiver. Results: These studies highlight the importance of molecular docking. Conclusion: Quantitative Structure-Activity Relationship (QSAR) and computer aided drug design (CADD) in predicting of possible pharmacological activities of these targets.