体内
C反应蛋白
炎症
生物
计算生物学
神经科学
受体
疾病
人类疾病
免疫学
细胞生物学
医学
遗传学
病理
作者
Shang‐Rong Ji,Shu-Hao Zhang,Yue Chang,Haiyun Li,Mingyu Wang,Jian‐Min Lv,Li Zhu,Patrick Ming‐Kuen Tang,Yi Wu
出处
期刊:Journal of Immunology
[American Association of Immunologists]
日期:2023-03-07
卷期号:210 (6): 699-707
被引量:23
标识
DOI:10.4049/jimmunol.2200831
摘要
Abstract C-reactive protein (CRP) is a highly conserved pentraxin with pattern recognition receptor–like activities. However, despite being used widely as a clinical marker of inflammation, the in vivo functions of CRP and its roles in health and disease remain largely unestablished. This is, to certain extent, due to the drastically different expression patterns of CRP in mice and rats, raising concerns about whether the functions of CRP are essential and conserved across species and how these model animals should be manipulated to examine the in vivo actions of human CRP. In this review, we discuss recent advances highlighting the essential and conserved functions of CRP across species, and propose that appropriately designed animal models can be used to understand the origin-, conformation-, and localization-dependent actions of human CRP in vivo. The improved model design will contribute to establishing the pathophysiological roles of CRP and facilitate the development of novel CRP-targeting strategies.
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