老化
细胞外基质
干细胞
组织工程
组分(热力学)
利基
基质(化学分析)
医学
材料科学
细胞生物学
生物
生物医学工程
遗传学
生物化学
复合材料
热力学
物理
作者
Rahel Schnellmann,Sharon Gerecht
标识
DOI:10.1038/s44222-023-00049-1
摘要
The extracellular matrix (ECM) is a key component of the stem-cell niche, and undergoes profound changes during ageing, affecting tissue mechanics and structure. Here, we argue that ECM alterations can be leveraged to engineer biomaterials to investigate age-mediated tissue dysfunction, and to design therapeutic strategies for age-related diseases. The extracellular matrix (ECM) is a key component of the stem-cell niche, and undergoes profound changes during ageing, affecting tissue mechanics and structure. Here, we argue that ECM alterations can be leveraged to engineer biomaterials to investigate age-mediated tissue dysfunction, and to design therapeutic strategies for age-related diseases.
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