一氧化氮
调节器
内体
功能（生物学）
体内
肾
细胞生物学
内皮
肾功能
势垒函数
医学
化学
内分泌学
生物
生物化学
生物技术
细胞内
基因
作者
Quan Jiang,Guiyu Song,Liying He,Xue Li,Bo Jiang,Qianxun Wang,Shaoxun Wang,Catherine Kim,Mahsa Nouri Barkestani,Roberto Lopez,Matthew Fan,Kujani Wanniarachchi,Maya Quaranta,Xuefei Tian,Arya Mani,Anjelica L. Gonzalez,Julie E. Goodwin,William C. Sessa,Shuta Ishibe,Dan Jane‐wit
标识
DOI：10.1016/j.kint.2024.05.007
摘要
ZFYVE21 is an ancient, endosome-associated protein that is highly expressed in endothelial cells (ECs) but whose function(s) in vivo are undefined. Here, we identified ZFYVE21 as an essential regulator of vascular barrier function in the aging kidney. ZFYVE21 levels significantly decline in ECs in aged human and mouse kidneys. To investigate attendant effects, we generated EC-specific Zfyve21
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