Palladium‐Catalyzed Aerobic γ‐C(sp3)−H Lactamization Using a NOx‐based Redox Mediator

Abstract Herein, we report a Pd‐catalyzed aerobic lactamization of unactivated γ ‐C( sp 3 )−H bonds of aliphatic carboxylic acids and amino acids derivatives. The utilization of Pd(OAc) 2 as a catalyst, along with catalytic AgNO 2 as an electron transfer mediator, circumvents the need for stoichiometric oxidants and demonstrates significant practicality.