A general model for skeletal dosimetry in mice is presented. Geometrical constructs were made for four general regions in the mouse skeleton, and dose factors for90 Sr and90Y were calculated using the MCNP Monte Carlo transport code. Then, an overall skeletal dose factor for the whole skeleton was derived based on the individual values and the fraction of the total skeleton that they were assumed to represent. The whole skeleton average values were 1.56 9 10-11Gy/dis for90 Sr and 1.74 9 10-11Gy/dis for90 Y.