Growth Factor‐Decorated Ti3C2 MXene/MoS2 2D Bio‐Heterojunctions with Quad‐Channel Photonic Disinfection for Effective Regeneration of Bacteria‐Invaded Cutaneous Tissue

Abstract Phototherapy has recently emerged as a competent alternative for combating bacterial infection without antibiotic‐resistance risk. However, owing to the bacterial endogenous antioxidative glutathione (GSH), the exogenous reactive oxygen species (ROS) generated by phototherapy can hardly behave desired antibacterial effect. To address the daunting issue, a quad‐channel synergistic antibacterial nano‐platform of Ti 3 C 2 MXene/MoS 2 (MM) 2D bio‐heterojunctions (2D bio‐HJs) are devised and fabricated, which possess photothermal, photodynamic, peroxidase‐like (POD‐like), and glutathione oxidase‐like properties. Under near‐infrared (NIR) laser exposure, the 2D bio‐HJs both yield localized heating and raise extracellular ROS level, leading to bacterial inactivation. Synchronously, Mo 4+ ions can easily invade into ruptured bacterial membrane, arouse intracellular ROS, and deplete intracellular GSH. Squeezed between the “ROS hurricane” from both internal and external sides, the bacteria are hugely slaughtered. After being further loaded with fibroblast growth factor‐21 (FGF21), the 2D bio‐HJs exhibit benign cytocompatibility and boost cell migration in vitro. Notably, the in vivo evaluations employing a mouse‐infected wound model demonstrate the excellent photonic disinfection towards bacterial infection and accelerated wound healing. Overall, this work provides a powerful nano‐platform for the effective regeneration of bacteria‐invaded cutaneous tissue using 2D bio‐HJs.