Copper/silver co-mediated three-component bicyclization for accessing indeno[1,2-c]azepine-3,6-diones

A new copper/silver-co-mediated three-component bicyclization of 1,6-enynes with ICF₂CO₂Et with TMSN₃ was reported, and used to produce difluorinated tetrahydroindeno[1,2-c]azepine-3,6-diones with moderate to good yields.