The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult lung transplantation report — 2021; Focus on recipient characteristics

For over 30 years, the International Society for Heart and Lung Transplantation (ISHLT) International Thoracic Organ Transplant (TTX) Registry has gathered data regarding transplant procedures, donor and recipient characteristics, and outcomes from a global community of transplant centers. Almost 70,000 adult lung transplant procedures have been reported to the Registry since its inception, each one providing an opportunity for a recipient with end-stage lung disease to regain quality of life and longevity. With each year's report, we provide more detailed analyses on a particular focus theme important to recipient outcomes. Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; allograft ischemic time; multiorgan transplantation; and donor and recipient size matching. 1 Chambers DC Cherikh WS Goldfarb SB et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-fifth adult lung and heart-lung transplant report-2018; focus theme: multiorgan transplantation. J Heart Lung Transplant. 2018; 37: 1169-1183 Abstract Full Text Full Text PDF PubMed Scopus (205) Google Scholar , 2 Chambers DC Cherikh WS Harhay MO et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1042-1055 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar , 3 Chambers DC Yusen RD Cherikh WS et al. The registry of the international society for heart and lung transplantation: thirty-fourth adult lung and heart-lung transplantation report-2017; focus theme: allograft ischemic time. J Heart Lung Transplant. 2017; 36: 1047-1059 Abstract Full Text Full Text PDF PubMed Scopus (325) Google Scholar , 4 Yusen RD Christie JD Edwards LB et al. The registry of the international society for heart and lung transplantation: thirtieth adult lung and heart-lung transplant report–2013; focus theme: age. J Heart Lung Transplant. 2013; 32: 965-978 Abstract Full Text Full Text PDF PubMed Scopus (400) Google Scholar , 5 Yusen RD Edwards LB Dipchand AI et al. The registry of the international society for heart and lung transplantation: thirty-third adult lung and heart-lung transplant report-2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant. 2016; 35: 1170-1184 Abstract Full Text Full Text PDF PubMed Scopus (337) Google Scholar , 6 Yusen RD Edwards LB Kucheryavaya AY et al. The registry of the international society for heart and lung transplantation: thirty-first adult lung and heart-lung transplant report–2014; focus theme: retransplantation. J Heart Lung Transplant. 2014; 33: 1009-1024 Abstract Full Text Full Text PDF PubMed Scopus (357) Google Scholar , 7 Yusen RD Edwards LB Kucheryavaya AY et al. The registry of the international society for heart and lung transplantation: thirty-second official adult lung and heart-lung transplantation report–2015; focus theme: early graft failure. J Heart Lung Transplant. 2015; 34: 1264-1277 Abstract Full Text Full Text PDF PubMed Scopus (332) Google Scholar In response to a changing regulatory environment, the ISHLT TTX Registry is undergoing an update in data acquisition, and the patient cohort examined in this report is therefore derived from the same data source or datasets as that examined in the 2019 annual reports. 2 Chambers DC Cherikh WS Harhay MO et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1042-1055 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar ,8 Khush KK Cherikh WS Chambers DC et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1056-1066 Abstract Full Text Full Text PDF PubMed Scopus (222) Google Scholar , 9 Rossano JW Singh TP Cherikh WS et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1028-1041 Abstract Full Text Full Text PDF PubMed Scopus (64) Google Scholar , 10 Hayes Jr, D Cherikh WS Chambers DC et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1015-1027 Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar We refer the reader to the 2019 and prior reports for a detailed description of the baseline characteristics of the cohort, and additional core analyses not directly related to the focus explored in this year's report. To complement the 2020 report which focussed on donor characteristics, the goal of this year's report was to focus entirely on changes in recipient factors over the past 3 decades and to identify important recipient characteristics and transplant processes that may influence post-transplant outcomes. Due to small numbers, heart-lung transplant recipient characteristics and transplant outcomes have not been included. This 38th annual adult lung transplant report is hence based on data submitted to the ISHLT TTX Registry on 67,493 adult recipients of deceased recipient transplants between January 1, 1992 and June 30, 2018. For over 30 years, the International Society for Heart and Lung Transplantation (ISHLT) International Thoracic Organ Transplant (TTX) Registry has gathered data regarding transplant procedures, donor and recipient characteristics, and outcomes from a global community of transplant centers. Almost 70,000 adult lung transplant procedures have been reported to the Registry since its inception, each one providing an opportunity for a recipient with end-stage lung disease to regain quality of life and longevity. With each year's report, we provide more detailed analyses on a particular focus theme important to recipient outcomes. Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; allograft ischemic time; multiorgan transplantation; and donor and recipient size matching. 1 Chambers DC Cherikh WS Goldfarb SB et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-fifth adult lung and heart-lung transplant report-2018; focus theme: multiorgan transplantation. J Heart Lung Transplant. 2018; 37: 1169-1183 Abstract Full Text Full Text PDF PubMed Scopus (205) Google Scholar , 2 Chambers DC Cherikh WS Harhay MO et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1042-1055 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar , 3 Chambers DC Yusen RD Cherikh WS et al. The registry of the international society for heart and lung transplantation: thirty-fourth adult lung and heart-lung transplantation report-2017; focus theme: allograft ischemic time. J Heart Lung Transplant. 2017; 36: 1047-1059 Abstract Full Text Full Text PDF PubMed Scopus (325) Google Scholar , 4 Yusen RD Christie JD Edwards LB et al. The registry of the international society for heart and lung transplantation: thirtieth adult lung and heart-lung transplant report–2013; focus theme: age. J Heart Lung Transplant. 2013; 32: 965-978 Abstract Full Text Full Text PDF PubMed Scopus (400) Google Scholar , 5 Yusen RD Edwards LB Dipchand AI et al. The registry of the international society for heart and lung transplantation: thirty-third adult lung and heart-lung transplant report-2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant. 2016; 35: 1170-1184 Abstract Full Text Full Text PDF PubMed Scopus (337) Google Scholar , 6 Yusen RD Edwards LB Kucheryavaya AY et al. The registry of the international society for heart and lung transplantation: thirty-first adult lung and heart-lung transplant report–2014; focus theme: retransplantation. J Heart Lung Transplant. 2014; 33: 1009-1024 Abstract Full Text Full Text PDF PubMed Scopus (357) Google Scholar , 7 Yusen RD Edwards LB Kucheryavaya AY et al. The registry of the international society for heart and lung transplantation: thirty-second official adult lung and heart-lung transplantation report–2015; focus theme: early graft failure. J Heart Lung Transplant. 2015; 34: 1264-1277 Abstract Full Text Full Text PDF PubMed Scopus (332) Google Scholar In response to a changing regulatory environment, the ISHLT TTX Registry is undergoing an update in data acquisition, and the patient cohort examined in this report is therefore derived from the same data source or datasets as that examined in the 2019 annual reports. 2 Chambers DC Cherikh WS Harhay MO et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1042-1055 Abstract Full Text Full Text PDF PubMed Scopus (203) Google Scholar ,8 Khush KK Cherikh WS Chambers DC et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: thirty-sixth adult heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1056-1066 Abstract Full Text Full Text PDF PubMed Scopus (222) Google Scholar , 9 Rossano JW Singh TP Cherikh WS et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric heart transplantation report - 2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1028-1041 Abstract Full Text Full Text PDF PubMed Scopus (64) Google Scholar , 10 Hayes Jr, D Cherikh WS Chambers DC et al. The international thoracic organ transplant registry of the international society for heart and lung transplantation: twenty-second pediatric lung and heart-lung transplantation report-2019; focus theme: donor and recipient size match. J Heart Lung Transplant. 2019; 38: 1015-1027 Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar We refer the reader to the 2019 and prior reports for a detailed description of the baseline characteristics of the cohort, and additional core analyses not directly related to the focus explored in this year's report. To complement the 2020 report which focussed on donor characteristics, the goal of this year's report was to focus entirely on changes in recipient factors over the past 3 decades and to identify important recipient characteristics and transplant processes that may influence post-transplant outcomes. Due to small numbers, heart-lung transplant recipient characteristics and transplant outcomes have not been included. This 38th annual adult lung transplant report is hence based on data submitted to the ISHLT TTX Registry on 67,493 adult recipients of deceased recipient transplants between January 1, 1992 and June 30, 2018.