镍
电泳剂
亲核细胞
催化作用
烷基
组合化学
光催化
还原消去
氧化加成
催化循环
偶联反应
反应性(心理学)
化学
有机化学
光催化
医学
病理
替代医学
作者
Justin B. Diccianni,Tianning Diao
标识
DOI:10.1016/j.trechm.2019.08.004
摘要
Advances in nickel-catalyzed cross-coupling reactions have expanded the chemical space of accessible structures and enabled new synthetic disconnections. The unique properties of Ni catalysts facilitate the activation of traditionally inert substrates, tolerate alkyl coupling partners that undergo decomposition via β-hydride (β-H) elimination with Pd, and enable stereoconvergent cross-couplings. The radical pathways accessed by Ni catalysts have been merged with photoredox and electrochemical catalysis to achieve new reactivity. The growing utility of Ni catalysis is, in no small part, due to advances in our fundamental understanding of the properties of Ni catalysts and the mechanisms by which the reactions occur. This review highlights recent important contributions to the field with an emphasis on studies that have afforded mechanistic insight.
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