免疫系统
免疫学
免疫
免疫监视
生物
伤亡人数
先天免疫系统
死亡人数
医学
环境卫生
作者
Xenia Ficht,Matteo Iannacone
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2020-09-18
卷期号:5 (51)
被引量:42
标识
DOI:10.1126/sciimmunol.aba2351
摘要
The liver is the target of several infectious, inflammatory, and neoplastic diseases, which affect hundreds of millions of people worldwide and cause an estimated death toll of more than 2 million people each year. Dysregulation of T cell responses has been implicated in the pathogenesis of these diseases; hence, it is critically important to understand the function and fate of T cells in the liver. Here, we provide an overview of the current knowledge on liver immune surveillance by conventional and invariant T cells and explore the complex cross-talk between immune cell subsets that determines the balance between hepatic immunity and tolerance.
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