Perilipin, obesity and insulin resistance

Perilipin is a lipid droplets-associated protein associating with the lipid droplets in adipocytes and steroidogenic cells.Because of its unique tissue distribution and molecular structure,Perilipin has a dual role in lipolysis regulation.Many studies have explored the significant association of Perilipin with obesity and insulin resistance.Furthermore,Perilipin ablation and its single nucleotide polymorphisms are significantly related to the development and susceptibility of obesity,insulin resistance.Perilipin may be a new useful target in treatment of these diseases. Key words: Perilipin ;  Obesity;  Insulin resistance