材料科学
涂层
苯乙烯
生物相容性
生物污染
化学工程
聚合物
表面改性
化学气相沉积
Zeta电位
接触角
图层(电子)
傅里叶变换红外光谱
X射线光电子能谱
复合材料
高分子化学
纳米技术
化学
纳米颗粒
共聚物
冶金
工程类
生物化学
膜
作者
Cuicui Su,Yiqi Hu,Qing Song,Yumin Ye,Lingling Gao,Peng Li,Ting Ye
标识
DOI:10.1021/acsami.9b22611
摘要
We report initiated chemical vapor deposition of model-graded polymer coatings enabling antibacterial, antifouling, and biocompatible surfaces. The graded coating was constructed by a bottom layer consisting of bactericidal poly(dimethyl amino methyl styrene) and a surface layer consisting of both dimethyl amino methyl styrene (DMAMS) and hydrophilic vinyl pyrrolidone (VP) moieties. Fourier transform infrared spectra showed existence of both DMAMS and VP in the coating with DMAMS as the major component, while X-ray photoelectron spectroscopy analysis and water contact angle measurement revealed a VP-enriched coating surface. The resultant coating exhibited more than 99.9% killing rate against both Gram-negative Escherichia coli and Gram-positive Bacillus subtilis despite the incorporation of VP on the surface. We believe that such bactericidal capability resulted because of its high surface zeta potential, which could be originated from the DMAMS units distributed both on the top surface and underneath. The graded coating achieved more than 85% bacterial fouling resistance than the pristine substrate, as well as improved biocompatibility, owing to the abundant surface lactam groups from the VP moiety. Furthermore, the graded coating maintained good bactericidal capability after multicycle challenges of bacterial solutions and was durable against continuous rigorous washing, suggesting potential applications in biomedical devices.
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