雷达51
生物
同源重组
遗传学
DNA修复
范科尼贫血
基因
基因组不稳定性
DNA损伤
计算生物学
DNA
细胞生物学
作者
Braulio Bonilla,Sarah R Hengel,McKenzie K Grundy,Kara A. Bernstein
出处
期刊:Annual Review of Genetics
[Annual Reviews]
日期:2020-11-23
卷期号:54 (1): 25-46
被引量:122
标识
DOI:10.1146/annurev-genet-021920-092410
摘要
Accurate DNA repair and replication are critical for genomic stability and cancer prevention. RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double-strand break repair, replication stress, and meiosis. RAD51 is an ATPase that forms a nucleoprotein filament on single-stranded DNA. RAD51 has the function of finding and invading homologous DNA sequences to enable accurate and timely DNA repair. Its paralogs, which arose from ancient gene duplications of RAD51, have evolved to regulate and promote RAD51 function. Underscoring its importance, misregulation of RAD51, and its paralogs, is associated with diseases such as cancer and Fanconi anemia. In this review, we focus on the mammalian RAD51 structure and function and highlight the use of model systems to enable mechanistic understanding of RAD51 cellular roles. We also discuss how misregulation of the RAD51 gene family members contributes to disease and consider new approaches to pharmacologically inhibit RAD51.
科研通智能强力驱动
Strongly Powered by AbleSci AI