IκB激酶
激酶
生物
坦克结合激酶1
先天免疫系统
丝氨酸苏氨酸激酶
磷酸化
内部收益率3
细胞生物学
IRF7
转录因子
炎症
信号转导
NF-κB
免疫学
免疫系统
遗传学
蛋白激酶A
MAP激酶激酶激酶
基因
作者
Ricardo J. Antonia,Robert S. Hagan,Albert S. Baldwin
标识
DOI:10.1016/j.tcb.2020.12.003
摘要
The inhibitor of kappa B kinase (IKK) family consists of IKKα, IKKβ, and the IKK-related kinases TBK1 and IKKε. These kinases are considered master regulators of inflammation and innate immunity via their control of the transcription factors NF-κB, IRF3, and IRF7. Novel phosphorylated substrates have been attributed to these kinases, a subset of which is not directly related to either inflammation or innate immunity. These findings have greatly expanded the perspectives on the biological activities of these kinases. In this review we highlight some of the novel substrates for this kinase family and discuss the biological implications of these phosphorylation events.
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