纳米探针
体内
谷胱甘肽
磁共振成像
化学
胶质瘤
病理
核磁共振
生物医学工程
纳米颗粒
癌症研究
材料科学
纳米技术
放射科
医学
生物化学
生物
物理
生物技术
酶
作者
Peisen Zhang,Jianfeng Zeng,Yingying Li,Chen Yang,Junli Meng,Yi Hou,Mingyuan Gao
标识
DOI:10.1002/anie.202014348
摘要
Studies reveal that malignant tumors feature uneven distributions of some key biomarkers across the entire tumorous region. Nevertheless, only very limited progress has been made towards non-invasive and quantitative detection of tumor-specific biomarkers in vivo, especially with clinically compatible imaging modalities. Reported here is an Fe3 O4 nanoparticle-based glutathione (GSH) responsive magnetic resonance imaging (MRI) probe that can form particle aggregates within tumors in vivo to give rise to strong GSH concentration dependent interlocked relaxivities. A quantitative correlation between the interlocked MRI signals and local GSH concentration was established, and further applied for mapping the heterogeneous distribution of GSH within an intracranial tumor (2.4 mm × 1.6 mm) in vivo. This methodology will offer a practical route for quantitatively mapping tumor-specific biomarkers in vivo with unlimited detection depth, which largely challenges optical-imaging-based approaches.
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