纳米探针
体内
谷胱甘肽
磁共振成像
化学
核磁共振
纳米颗粒
材料科学
纳米技术
放射科
医学
生物化学
生物
物理
生物技术
酶
作者
Peisen Zhang,Jianfeng Zeng,Yingying Li,Chen Yang,Junli Meng,Yi Hou,Mingyuan Gao
标识
DOI:10.1002/anie.202014348
摘要
Abstract Studies reveal that malignant tumors feature uneven distributions of some key biomarkers across the entire tumorous region. Nevertheless, only very limited progress has been made towards non‐invasive and quantitative detection of tumor‐specific biomarkers in vivo, especially with clinically compatible imaging modalities. Reported here is an Fe 3 O 4 nanoparticle‐based glutathione (GSH) responsive magnetic resonance imaging (MRI) probe that can form particle aggregates within tumors in vivo to give rise to strong GSH concentration dependent interlocked relaxivities. A quantitative correlation between the interlocked MRI signals and local GSH concentration was established, and further applied for mapping the heterogeneous distribution of GSH within an intracranial tumor (2.4 mm × 1.6 mm) in vivo. This methodology will offer a practical route for quantitatively mapping tumor‐specific biomarkers in vivo with unlimited detection depth, which largely challenges optical‐imaging‐based approaches.
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