The effect of 3,7-diazabicyclo[3.3.1]nonanescontaining monoterpenoid moieties on the physical activity of mice.

The aim of this work is to study the effect of agents combining fragments of monoterpenoids and 3,7diazabicyclo[3.3.1]nonane(bispidine) on the performance of mice.Physical endurance was studied using two tests: exhaustive swimming with a load of 7% of body weight (after single dosing) and exhaustive treadmill running (after single dosing and a 7-day administration).It has been shown for the first time that derivatives of monoterpenoids with 3,7-diazabicyclo[3.3.1]nonanemoiety containing methyl substituents at positions 1 and 5 have a stimulatory effect on the performance of mice, which exceeds the effect of the reference drug bromantane after single dosing.Compound K1-458, which contains (-)-myrtenal residues linked to a bispidine fragment via amino groups, is the most effective in increasing the duration of running and swimming at a dose of 100 mg/kg after single intragastric administration.It has been also established that the LD50 for these compounds exceeds 1,000 mg/kg.