穹窿
白质
扣带回(脑)
认知功能衰退
部分各向异性
钩束
颞叶
神经科学
心理学
磁共振弥散成像
下纵束
认知
磁共振成像
海马体
医学
内科学
痴呆
疾病
放射科
癫痫
作者
Derek B. Archer,Elizabeth E. Moore,Niranjana Shashikumar,Logan Dumitrescu,Kimberly R. Pechman,Bennett A. Landman,Katherine A. Gifford,Angela L. Jefferson,Timothy J. Hohman
标识
DOI:10.1016/j.neurobiolaging.2020.05.001
摘要
Although hippocampal volume has served as a long-standing predictor of cognitive decline, diffusion magnetic resonance imaging studies of white matter have shown similar relationships. Still, it remains unclear if gray matter and white matter interact to predict cognitive impairment and longitudinal decline. Here, we investigate whether free-water (FW) and FW-corrected fractional anisotropy (FAT) within medial temporal lobe white matter tracts provides meaningful contribution to cognition and cognitive decline beyond hippocampal volume. Using data from the Vanderbilt Memory & Aging Project (n = 319), we found that FW was associated with baseline memory and executive function beyond that of hippocampal volume and other comorbidities. Longitudinal analyses demonstrated significant interactions of hippocampal volume and inferior longitudinal fasciculus (p = 0.043) and cingulum bundle (p = 0.025) FAT on memory decline and with fornix FAT (p = 0.025) on decline in executive function. Results suggest that FW metrics of white matter have a unique role in cognitive decline and should be included in theoretical models of aging, cerebrovascular disease, and Alzheimer’s disease.
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