视网膜色素上皮
黄斑变性
视网膜
糖尿病性视网膜病变
早产儿视网膜病变
医学
药品
药物输送
视网膜
视网膜病变
靶向给药
眼科
神经科学
药理学
生物
化学
糖尿病
内分泌学
怀孕
遗传学
有机化学
胎龄
作者
Marilena Bohley,Andrea E. Dillinger,Ernst R. Tamm,Achim Goepferich
标识
DOI:10.1016/j.drudis.2022.05.024
摘要
The retinal pigment epithelium (RPE) plays a crucial part in sight-threatening diseases. In this review, we shed light on the pivotal implication of the RPE in age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity; and explain why a paradigm shift toward targeted RPE therapy is needed to efficiently fight these retinal diseases. We provide guidance for the development of RPE-specific nanotherapeutics by giving a comprehensive overview of the possibilities and challenges of drug delivery to the RPE and highlight successful nanotherapeutic approaches targeting the RPE.
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