伯氏疟原虫
疟疾
免疫系统
医学
免疫学
寄生虫寄主
药理学
生物
计算机科学
万维网
作者
Naisargee Patel,Aarushi Zinzuvadia,Mitali Prajapati,Rajeev K. Tyagi,Sarat K. Dalai
出处
期刊:Future Microbiology
[Future Medicine]
日期:2022-08-01
卷期号:17 (12): 931-941
被引量:1
标识
DOI:10.2217/fmb-2021-0298
摘要
Aims: Development of resistance by the malaria parasite, a systemic inflammatory and infectious pathogen, has raised the need for novel efficacious antimalarials. Plant-derived natural compounds are known to modulate the immune response and eradicate the infectious pathogens. Therefore we carried out experiments with swertiamarin to dissect its anti-inflammatory and immunomodulatory potential. Materials & methods: We carried out studies in Swiss albino mice that received infectious challenge with Plasmodium berghei and swertiamarin treatment in a prophylactic manner. Results & conclusion: Oral administration of swertiamarin prior to infectious challenge with P. berghei in experimental mice showed delayed parasite development as compared with untreated control. IFN-γ and IL-10 appeared to be adapted/modulated by regular swertiamarin treatment. Further, withdrawal of swertiamarin pressure did not affect parasite replication. However, the short half-life of swertiamarin limited its long-lasting therapeutic effect, requiring higher and frequent dosing schedules.
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