番茄红素
医学
安慰剂
骨质疏松症
内科学
N-末端末端肽
安慰剂对照研究
内分泌学
骨重建
临床试验
代理终结点
激素替代疗法(女性对男性)
生理学
抗氧化剂
双盲
睾酮(贴片)
骨钙素
病理
生物
生物化学
碱性磷酸酶
替代医学
酶
作者
Meeta Meeta,Sudhaa Sharma,Jyothi Unni,Sunila Khandelwal,Ambuja Choranur,Sonia Malik
标识
DOI:10.4103/jmh.jmh_61_22
摘要
The effect of lycopene (LycoRed) supplementation was evaluated in healthy postmenopausal women by biochemical markers for cardiovascular protection and osteoporosis protection.This was a multi-centric placebo-controlled double-blind randomized clinical trial that screened 198 postmenopausal women at 21 centers across 12 cities in India. Levels of lycopene, lipid profile, high-risk C-reactive protein, and bone turnover markers: amino-terminal propeptide of Type I collagen (P1NP) and C-terminal telopeptide of Type I collagen (β-CTx) were measured at baseline and 6 months postsupplementation with LycoRed or placebo.The study was completed with 57 of the 100 women on LycoRed 8 mg (antioxidant potency is equivalent to 24 mg of lycopene) and 43 placebos for 6 months by randomization.Rise in serum lycopene and effect of serum lycopene on surrogate markers of cardiovascular health and bone health.LycoRed supplementation increases lycopene levels and P1NP and nonsignificant fall in β-CTx levels in healthy postmenopausal women.Lycopene supplementation in Indian menopausal women may confer protection from osteoporosis as shown by the directional change in the surrogate biochemical markers. This study can form a basis for larger studies with different doses to understand the effect of lycopene to prevent and act as adjuvant treatment on clinical endpoints for cardiovascular disease (CVD) and bone health.
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