材料科学
伤口愈合
膜
纳米纤维
静电纺丝
肿胀 的
生物医学工程
纳米颗粒
化学工程
体内
纳米技术
化学
复合材料
聚合物
外科
医学
生物技术
工程类
生物
生物化学
作者
Yan Chu,Shuo Chai,Fēi Li,Chun Han,Xiaoyu Sui,Tingting Liu
出处
期刊:Polymers
[MDPI AG]
日期:2022-06-16
卷期号:14 (12): 2454-2454
被引量:4
标识
DOI:10.3390/polym14122454
摘要
Past studies have shown that the hot spring effect can promote wound healing. Mild thermal stimulation and metal ions can promote angiogenesis. In this study, the hot spring effect was simulated by thermosensitive PNIPAAm hydrogel loaded with copper sulfide nanoparticles. Heat stimulation could be generated through near-infrared irradiation, and copper ions solution could be pulsed. On the other hand, the CS/PVA nanofiber membrane was attached to the bottom of the hydrogel to simulate the extracellular matrix structure, thus improving the wound healing ability. The CS/PVA nanofiber membrane was prepared by electrospinning, and the appropriate prescription and process parameters were determined. The nanofiber membrane has uniform pore size, good water absorption and permeability. The poor mechanical properties of PNIPAAm hydrogel were improved by adding inorganic clay. The temperature of the hydrogel loaded with CuS nanoparticles reached 40 °C under near-infrared light irradiation for 20 min, and the release rate of Cu2+ reached 26.89%. The wound-healing rate of the rats in the combined application group reached 79.17% at 13 days, demonstrating superior results over the other control groups. Histological analyses show improved inflammatory response at the healed wound area. These results indicate that this combined application approach represents a promising wound treatment strategy.
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