心肌肥大
抑制器
肌肉肥大
心力衰竭
泛素连接酶
生物
病态的
医学
内科学
心脏病学
内分泌学
生物信息学
心肌肥大
心室肥大
钥匙(锁)
治疗方法
泛素蛋白连接酶类
病理
作者
Jiayi Liu,Wei Li,Ke-Qiong Deng,Song Tian,Hui Liu,Hongjie Shi,Qian Fang,Zhen Liu,Ze Chen,Tian Tian,Shanyu Gan,Fengjiao Hu,Manli Hu,Xu Cheng,Yan-Xiao Ji,Peng Zhang,Zhi-Gang She,Xiao-Jing Zhang,Shaoze Chen,Jingjing Cai
出处
期刊:Circulation Research
[Lippincott Williams & Wilkins]
日期:2022-04-19
卷期号:130 (10): 1586-1600
被引量:67
标识
DOI:10.1161/circresaha.121.318866
摘要
Our findings provide the first evidence supporting Trim16 as a novel suppressor of pathological cardiac hypertrophy and indicate that targeting the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.
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