纳米材料
大型水蚤
达尼奥
纳米毒理学
里巴利摇蚊
生物
环境化学
化学
纳米技术
材料科学
生态学
斑马鱼
纳米颗粒
毒性
生物化学
有机化学
胆
基因
吸浆虫
作者
Becky J Curtis,Nicholas J. Niemuth,Evan Bennett,Angela Schmoldt,Olaf Mueller,Aurash Mohaimani,Elizabeth D. Laudadio,Yu Shen,Jason C. White,Robert J. Hamers,Rebecca Klaper
标识
DOI:10.1038/s41565-022-01096-2
摘要
Physico-chemical characteristics of engineered nanomaterials are known to be important in determining the impact on organisms but effects are equally dependent upon the characteristics of the organism exposed. Species sensitivity may vary by orders of magnitude, which could be due to differences in the type or magnitude of the biochemical response, exposure or uptake of nanomaterials. Synthesizing conclusions across studies and species is difficult as multiple species are not often included in a study, and differences in batches of nanomaterials, the exposure duration and media across experiments confound comparisons. Here three model species, Danio rerio, Daphnia magna and Chironomus riparius, that differ in sensitivity to lithium cobalt oxide nanosheets are found to differ in immune-response, iron-sulfur protein and central nervous system pathways, among others. Nanomaterial uptake and dissolution does not fully explain cross-species differences. This comparison provides insight into how biomolecular responses across species relate to the varying sensitivity to nanomaterials.
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