Drug Survival of Biologic Therapy in Elderly Patients With Rheumatoid Arthritis Compared With Nonelderly Patients: Results From the Korean College of Rheumatology Biologics Registry.

医学 内科学 类风湿性关节炎 痹症科 不利影响 观察研究 甲氨蝶呤 物理疗法
作者
Seung Eun Jung,Sang-Won Lee,Jaewoo Song,Sung-Hwan Park,Yong Beom Park
出处
期刊:Jcr-journal of Clinical Rheumatology [Ovid Technologies (Wolters Kluwer)]
卷期号:28 (1): e81-e88 被引量:1
标识
摘要

Although the proportion of elderly patients with rheumatoid arthritis (RA) is increasing, the persistency of biologic therapy in elderly patients requires additional investigation. This study evaluated the drug survival of biologic therapy and associated factors in elderly compared with nonelderly patients.This longitudinal observational study included RA patients who were enrolled in the Korean College of Rheumatology Biologics Registry (NCT01965132, started from January 1, 2013) between 2013 and 2015. We compared the retention rate of biologic therapy between elderly (age ≥70 years) and nonelderly (age <70 years) patients, and investigated the causes and predictors of biologic withdrawal in both groups.Of 682 patients, 122 were aged 70 years or older. The retention rate of biologic therapy at 24 months was 57.8% and 46.5% in nonelderly and elderly patients, respectively (p = 0.027). Biologic withdrawal due to adverse events and inefficacy within 24 months was not significantly different between the 2 groups, although adverse events were more common in elderly patients (20.6% vs 12.8%, p = 0.360). Drug withdrawal due to patient refusal was more common in elderly patients (9.8% vs 1.8%, p < 0.001). In elderly patients, biologic withdrawal was associated with current smoking and older age at disease onset, whereas the use of tumor necrosis factor inhibitors, nonuse of methotrexate, and combination of corticosteroid were important in nonelderly patients.Elderly RA patients are more likely to discontinue biologic agents within 24 months. To increase the retention rate of biologic therapy, rheumatologists should consider patient characteristics before and during biologic therapy.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
酷波er应助ZYK采纳,获得10
1秒前
小福泥完成签到 ,获得积分10
3秒前
Anar发布了新的文献求助10
3秒前
4秒前
研友_nqaBGn发布了新的文献求助10
4秒前
5秒前
666完成签到,获得积分10
8秒前
10秒前
笑嘻嘻完成签到,获得积分10
10秒前
11秒前
11秒前
11秒前
xxy发布了新的文献求助10
11秒前
大宇发布了新的文献求助10
11秒前
优雅的怀莲完成签到,获得积分10
11秒前
11秒前
12秒前
12秒前
duolaAmeng完成签到,获得积分10
12秒前
慕青应助666采纳,获得10
12秒前
阿黎发布了新的文献求助10
13秒前
小子弹完成签到,获得积分10
14秒前
15秒前
JamesPei应助公西冥幽采纳,获得10
15秒前
李刚发布了新的文献求助10
15秒前
孤独无极发布了新的文献求助10
16秒前
ZYK发布了新的文献求助10
17秒前
充电宝应助pplynl采纳,获得30
17秒前
小子弹发布了新的文献求助10
18秒前
赘婿应助drjj采纳,获得10
18秒前
小马甲应助Anar采纳,获得10
18秒前
伯赏凝旋完成签到 ,获得积分10
20秒前
hyekyo发布了新的文献求助10
20秒前
开朗的香水蘑菇完成签到,获得积分10
21秒前
木木完成签到,获得积分10
22秒前
KK完成签到,获得积分10
24秒前
照烧鸡腿发布了新的文献求助10
26秒前
helloragdoll完成签到,获得积分10
26秒前
ABEDO完成签到 ,获得积分10
28秒前
高分求助中
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 1000
Corrosion and Oxygen Control 600
Python Programming for Linguistics and Digital Humanities: Applications for Text-Focused Fields 500
Heterocyclic Stilbene and Bibenzyl Derivatives in Liverworts: Distribution, Structures, Total Synthesis and Biological Activity 500
重庆市新能源汽车产业大数据招商指南(两链两图两池两库两平台两清单两报告) 400
Division and square root. Digit-recurrence algorithms and implementations 400
行動データの計算論モデリング 強化学習モデルを例として 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2546745
求助须知:如何正确求助?哪些是违规求助? 2175896
关于积分的说明 5601536
捐赠科研通 1896703
什么是DOI,文献DOI怎么找? 946382
版权声明 565379
科研通“疑难数据库(出版商)”最低求助积分说明 503569