A Highly Sensitive Electrochemical Sensor Based on β -cyclodextrin Functionalized Multi-Wall Carbon Nanotubes and Fe 3 O 4 Nanoparticles for Rutin Detection

A functionalized nanocomposites composed of multi-wall carbon nanotubes (MWCNTs), Fe 3 O 4 nanoparticles (Fe 3 O 4 ) and β -cyclodextrin (CD) was prepared. The MWCNTs-CD-Fe 3 O 4 modified glassy carbon electrode (GCE) displayed good electrochemical response towards rutin (Ru). The detection linear range and the detection limit of the electrochemical sensor for Ru were 0.02–10 μ M and 16.4 nM, respectively. The results of actual sample detection were consistent with those of ultra-high performance liquid chromatography (UHPLC). The modified materials were also analyzed by UV-visible spectroscopy (UV-Vis)，transmission electrode microscope (TEM), and electrochemical impedance spectroscopy (EIS), respectively. The prepared nanocomposites integrate the excellent electric conductivity and electrocatalytic activity of MWCNTs and Fe 3 O 4 , as well as the disperse ability of CD, and may play a synergistic role in the electrochemical response of the modified electrode towards Ru. Moreover, the prepared sensor had good anti-interference ability and potential application in the actual content detection of drugs.