Changes of Th17 cells, regulatory T cells, Treg/Th17, IL-17 and IL-10 in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

FOXP3型 Treg细胞 荟萃分析 白细胞介素2受体 医学 白细胞介素17 内科学 子群分析 糖尿病 2型糖尿病 调节性T细胞 免疫学 2型糖尿病 白细胞介素10 内分泌学 胃肠病学 炎症 T细胞 细胞因子 免疫系统
作者
Changyan Zi,Liyun He,Huan Yao,Yuan Ren,Tingting He,Yongxiang Gao
出处
期刊:Endocrine [Springer Nature]
卷期号:76 (2): 263-272 被引量:7
标识
DOI:10.1007/s12020-022-03043-6
摘要

PurposeThe aim of this study was to investigate the changes of Helper T cells 17 (Th17 cells), Regulatory T cells (Treg cells), Treg/Th17, Interleukin-17 (IL-17) and Interleukin-10 (IL-10) in patients with type 2 diabetes mellitus (T2DM).MethodsFour electronic resource databases were searched from their inception to 1 August 2021. Case-control studies about changes of Th17 cells, Treg cells, Treg/Th17, IL-17 and IL-10 in patients with T2DM were retrieved. We performed this meta-analysis via RevMan V.5.3 and Stata14.Results20 studies with 1242 individuals were included in the meta-analysis. Compared with the controls, the patients with T2DM had significantly increased levels of percentage of Th17 cells (SMD, 1.74; 95% CI, 0.47–3.01; p < 0.001), IL-17 (SMD, 2.17; 95% CI, 0.06–4.28; p < 0.001), IL-10 (SMD, 1.20; 95% CI, 0.81–1.59; p = 0.003), but decreased levels of percentage of Treg cells (SMD, −1.17; 95% CI, −2.22 to −0.13; p < 0.001) and Treg/Th17 ratio (SMD, −4.43; 95% CI, −7.07 to −1.78; p < 0.001). Subgroup analysis showed that percentage of CD4+CD25+FOXP3+ Tregs (SMD, −2.36; 95% CI, −3.19 to −1.52; p = 0.003) in patients was notably lower than controls. While not significant changes were found in the percentage of CD4+CD25+Tregs (SMD, 0.03; 95% CI, −0.34–0.40; p = 0.63) between patients and controls. For plasma or serum IL-10, a higher plasma IL-10 level (SMD,1.37; 95% CI, 0.92–1.82; p = 0.01) was observed in T2DM. While serum IL-10 (SMD, 0.73; 95% CI, 0.35–1.12; p = 0.79) had no obvious difference between patients and controls. For ELISA or flow cytometry, IL-10 (SMD, 1.2; 95% CI, 0.71–1.70; p = 0.001) was higher in T2DM patients by using detection method of ELISA. Yet IL-10 using flow cytometry and subgroup analysis of IL-17 had no significant differences.ConclusionsAdaptive immune system indeed plays an essential role in the process of T2DM. Imbalance between Th17 and Treg triggers pro-inflammatory environment in patients with T2DM.
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