Nanoplatform-mediated calcium overload for cancer therapy

Mitochondria, as the "the power plants" of cells, have been extensively studied because of their biological functions of providing energy and participating in signaling pathways. In parallel, calcium (Ca²⁺) plays a vital role in the homeostasis balance and function coordination of mitochondria, especially in cancer cells which metabolize frequently to maintain their growth. On this basis, Ca²⁺ overload has been an efficient, yet safe theranostic model for cancer therapy, by activating mitochondrial apoptosis pathways to achieve cancer suppression. However, the integration of functional units mediating Ca²⁺ overload into the nanoplatform remains a difficult but significant task. This review aims to highlight meaningful designs of nanoplatforms for Ca²⁺ overload, including monotherapy and combination therapy. In addition, perspectives on further development of Ca²⁺ overload are provided, mainly emphasizing scientific restrictions and future exploitation directions.