医学
免疫疗法
儿童癌症
重症监护医学
小儿癌症
小儿肿瘤学
癌症
内科学
作者
Eui-Hyoung Hwang,Elias Sayour,Catherine Flores,Gerald A. Grant,Robert J. Wechsler‐Reya,Lan Hoang-Minh,Mark W. Kieran,Joanne Salcido,Robert M. Prins,John Figg,Michael Platten,Kate M. Candelario,Paul G. Hale,Jason E. Blatt,Lance S. Governale,Hideho Okada,Duane A. Mitchell,Ian F. Pollack
出处
期刊:Nature cancer
[Springer Nature]
日期:2022-01-20
卷期号:3 (1): 11-24
被引量:24
标识
DOI:10.1038/s43018-021-00319-0
摘要
Pediatric central nervous system tumors are the most common solid malignancies in childhood, and aggressive therapy often leads to long-term sequelae in survivors, making these tumors challenging to treat. Immunotherapy has revolutionized prospects for many cancer types in adults, but the intrinsic complexity of treating pediatric patients and the scarcity of clinical studies of children to inform effective approaches have hampered the development of effective immunotherapies in pediatric settings. Here, we review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.
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