cis-bis(N-benzoyl-N′,N′-dibenzylthioureido)platinum(II): Synthesis, molecular structure and its interaction with human and bovine serum albumin

In this paper, the title compound was synthesized from N-benzoyl-N 0 ,N 0 -dibenzyl thiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X-ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N 0 ,N 0 -dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C-H C, C-H S and H H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, K b , presenting values of around 10 5 M 1 and 10 4 M 1 , respectively. Thermodynamic parameters (DG, DH and DS) suggest spontaneous interactions between complex and the proteins.