丙二腈
化学
催化作用
分子
组分(热力学)
有机化学
组合化学
热力学
物理
作者
Michaïl N. Elinson,A. N. Vereshchagin,Sergey I. Bobrovsky,Ruslan F. Nasybullin,Alexey I. Ilovaisky,Valentina M. Merkulova
标识
DOI:10.1016/j.crci.2015.11.002
摘要
A new type of catalytic cascade pseudo four-component reaction has been found. The simple and facile pseudo four-component reaction of salicylaldehydes and cyclic or heterocyclic ketones with two molecules of malononitrile catalyzed by sodium acetate at ambient temperature results in the formation of 4-substituted 2-amino-4H-chromenes in 70–90% yields. Thus, a new simple and efficient ‘one-pot’ method to synthesize substituted 2-amino-4H-chromenes was found directly from such reasonable starting compounds as salicylaldehydes, cyclic or heterocyclic ketones and malononitrile.
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