生发中心
免疫分型
淋巴瘤
体细胞
B细胞
起源细胞
生物
基因
抗原
遗传学
免疫学
抗体
作者
Ralf Küppers,Ulf Klein,Martin‐Leo Hansmann,Klaus Rajewsky
标识
DOI:10.1056/nejm199911113412007
摘要
The origin of human lymphomas has been studied by various approaches, including histology and immunophenotyping. In some types of lymphoma these studies suggested the cellular origin, but in many instances the origin could not be identified. When somatic mutations of the genes for the variable region of the B-lymphocyte antigen receptor proved to be a hallmark of germinal-center B cells and their descendants, sequence analysis of the variable-region genes of B-cell lymphomas offered a molecular approach to studying the origin of the tumors. Before discussing the results of these studies, we outline the human peripheral B-cell repertoire and its generation. . . .
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