TSGOE: A web tool for tissue-specific gene ontology enrichment

Gene Ontology (GO) is one of the most popular Bioinformatics resources for studying the functional relationships between genes. GO enrichment analysis has become a routine method for gene function analysis, and it is of great significance for revealing the molecular mechanism of biology. However, existing GO enrichment analysis tools do not take into account tissue specificity and cannot distinguish gene sets that users interested. In this paper, we propose an easy-to-use web application, termed as TSGOE, which allows users to perform tissue specific-based GO enrichment analysis conveniently. Besides, TSGOE also provides rigorous statistical testing to improve the reliability of analytical result. To evaluate its performance, we apply TSGOE on several cancer-related gene lists. The experimental results show that our tool perform better than traditional GO enrichment analysis method. TSGOE is available at http://120.77.47.2:5678.