Tone frequency representation beyond the tonotopic map: Cross-correlation between ongoing activity in the rat auditory cortex

Functional maps play crucial roles in the neural representations of the sensory cortices, although such representations occasionally extend beyond these maps. For example, the auditory cortex exhibits distinct tonotopic activation at the onset of tone, which is followed by rapid decays in the majority of neuronal signals and ongoing activities in only a small number of neurons. Such ongoing activity should be maintained by the cortical states. To better understand maintenance of ongoing activity beyond that triggered directly by stimuli, we used a rat model. Here, we hypothesized that neural correlations between local field potentials (LFPs) within a local area of the auditory cortex may serve as a measure of the cortical state underlying ongoing activity. We densely mapped the auditory cortex of rats and demonstrated that cross-correlation patterns of ongoing activity were highly decodable. Informative features were widely distributed over the auditory cortex and across multiple frequency bands. Furthermore, acoustic trauma disrupted tonotopic representation at the onset but did not affect neural representations by the correlation of ongoing activities. These results suggest that cross-correlations of LFP within the auditory cortex represent frequencies of sustained auditory stimuli, and that these representations are made beyond direct tonotopic activation at stimulus onset.