医学
乙肝疫苗
胎龄
效价
乙型肝炎
出生体重
妊娠期
甲肝疫苗
不利影响
儿科
抗体
胃肠病学
产科
内科学
乙型肝炎病毒
免疫学
怀孕
免疫
乙型肝炎表面抗原
病毒
生物
遗传学
作者
Abid Hossain Mollah,Nurun Naher,Shamsur Rahman,A Q Chowdhury
出处
期刊:PubMed
日期:2012-01-01
卷期号:21 (1): 109-13
被引量:4
摘要
This cross sectional study was conducted to assess seroprotection by completed 3 doses of hepatitis B vaccine in routine EPI schedule in preterm & LBW as well as term appropriate weight babies and to compare the immune response among them. The study was conducted in EPI centre of Dhaka Medical College Hospital where 50 preterm (<37 completed weeks of gestation) and low birth weight (<2500 gm) infants enrolled in group A and 50 term (37-42 completed weeks of gestation) appropriate weight (≥2500 gm) in group B. All infants were immunized with 3 doses of hepatitis B vaccine according to EPI schedule and first vaccine was given at 6 weeks after birth and subsequent doses are given at one month interval. Adverse events were monitored. Anti HBs titre was determined 1 month after 3rd dose of vaccine from serum by ELISA method (VITROS anti HBs reagent pack). Seroprotectivity (anti HBs titres >10 mIU/ml) of hepatitis B vaccine after 3 doses were 94% and 98% in group A and B respectively (p>0.05). However, the preterm infants had a lower geometric mean titre of antibodies after 3 doses of vaccine than did the term infants (92.75 mIU/ml vs. 310.59 mIU/ml respectively; p<0.001). After 3 doses of hepatitis B vaccine though the seroprotective anti HBs titre (i.e. >10 mIU/ml) was ~96% irrespective of gestational age and birth weight but good antibody titre (i.e. >100 mIU/ml) was found among preterm babies having gestational age >34 weeks (73.6%) and birth weight >2000 gm (64%).
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