Click-Enabled Grafting for Adaptive Chiral Recognition in Porous Crystals

Reticular frameworks are promising candidates for chiral environments, yet most rely on static stereogenic units, overlooking adaptive host-guest interactions in enantioselective recognition. We report a modular postsynthetic click strategy to install amino acid-derived peptidic moieties into UiO-68 frameworks without compromising crystallinity. Only the histidine-functionalized material exhibits high enantioselectivity for cetirizine. Simulations reveal adaptive interaction pockets, emphasizing the importance of local pore reorganization in chiral molecular recognition.