Unraveling the mechanism of Lianqiaobaidu powder in viral myocarditis: Complementary actions within cardiac cell types

• Lianqiaobaidu powder alleviates cardiac dysfunction and injury in CVB3-infected mice. • Nodakenin, Isosakuranin, and Epicatechin gallate are key LQBDP anti-VMC constituents. • Nodakenin inhibits CVB3 replication in cardiac fibroblasts via the MEK pathway. • Isosakuranin reduces inflammation in CVB3-infected macrophages via the RAGE pathway. • Epicatechin gallate blocks CVB3-induced cardiomyocyte apoptosis via the TNFR pathway.