hnRNPA2B1 Promotes Malignant Phenotype and Tumor Progression of Gastric Cancer Cells by Regulating Macrophage M2 Polarization

ABSTRACT To investigate the mechanism by which heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1) regulates the maturation of LncRNA MM2P to promote M2 polarization of macrophages in gastric cancer. In vitro experiments showed that hnRNPA2B1 could promote M2 polarization of iBMDM cells, enhance the maturation and expression of MM2P, and increase STAT6 phosphorylation levels. When MM2P was knocked out, hnRNPA2B1 could no longer further promote cell M2 polarization. iBMDM cells with hnRNPA2B1‐induced M2 polarization could enhance the metastasis and invasion of MFC cells, improve clonogenic ability, and increase cell viability. In vivo experiments demonstrated that hnRNPA2B1 could promote the infiltration and polarization of CD206 cells and facilitate tumor growth. hnRNPA2B1 can regulate macrophage M2 polarization by promoting the maturation and expression of MM2P, thereby enhancing the malignant behavior of gastric cancer cells and tumor growth.