Selective Continuous Flow Processes Using Fluorine Gas

The use of continuous gas–liquid flow reactors for processes involving fluorine gas is reviewed. Falling film, microbubble, and laminar flow reactors that have been adapted to carry out direct fluorination reactions are described, and a range of selective fluorination reactions involving direct fluorination of a variety of aromatic, dicarbonyl, diester and benzaldehyde derivatives are presented as well as related continuous flow oxidation processes (such as epoxidation reactions and the transformation of amines to nitro derivatives) involving fluorine gas.