Aerobic Glycolysis and Its Role in Maintenance of High O2 Tensions in the Teleost Retina

Lactic acid production in the presence of high oxygen tensions (aerobic glycolysis) was found to occur in the teleost retina. Forty-two percent more glucose was utilized and 33% more lactic acid was produced under anaerobic than under aerobic conditions. Glycolysis was inhibited 33% by elevated oxygen (Pasteur effect), and it was further demonstrated that glycolysis is dependent upon the integrity of the retinal cells, being almost completely abolished by cellular disruption.