Progress of EGFR-Targeted PET/SPECT Molecular Imaging

The morbidity and mortality of cancer has been increasing year by year.Molecular targeted therapy has brought a new revolution for cancer therapy. Epidermal growth factor receptor(EGFR) plays an key role in the occurrence and development of carcinoma. So EGFR-targeted therapy has become hotspot in recent years. Currently, there are a variety of EGFR-targeted drugs used clinically, however, the overall efficiency is unsatisfied. Large scale of studies have shown that the overexpression and/or mutation of EGFR affected the efficiency significantly. Therefore, it seems to be particularly important that evaluate the expression level and/or mutation of EGFR in the tumor before treatment accurately. Molecular imaging can achieve the image of the biological processes in cellular and molecular level in vivo, and carry on qualitative and quantitative calculation,which makes it possible that reveal the expression level and/or mutation of EGFR in vivo. This article briefly introduce the progress of EGFR-targeted molecular imaging,and the imaging and function of different probes. Are compared and analysed, so that can b enefit the development of m olecular imaging probes and EGFR-targeted molecular imaging researchment.