Physical and Chemical Nature Research of Antibacterial Peptide Spinigerin α

Based on the successful cloning and expression of Spinigerin antimicrobial peptide gene,this paper conducts a research on the effects of external conditions of antibacterial characteristics,temperature,pH stability of Spinigerin peptide on its antibacterial activity.Results show that: the concentration of Spinigerin α,temperature,pH are all have important impact on its bacteriostatic activity,the smallest antibacterial activities on Staphylococcus aureus,Escherichia coli,Salmonella are 1.52%,3.13% and 12.5% respectively;when Spinigerin α is heated to 60-100℃,the bacteriostatic effect is obvious,while heated to 121℃,the effect begins to decline;when the pH is nearly neutral environment(6.0-8.0),Spinigerin antibacterial peptides have the strongest antibacterial activity.