A clinical study of 57 patients with natural killer/T-cell lymphoma,nasal type

Objective:To investigate the clinical features in patients with NKTLNT,the treatment response between radiotherapy as initial treatment and chemotherapy as initial treatment,and the influence of different therapy on 5-year survival.Methods:The deta of 57 patients with Ann Arbor stage IE NKTLNT who underwent radiotherapy+chemotherapy,or chemotherapy+radiotherapy,were retrospectively reviewed.These patients were divided into two groups according to initial treatment:radiotherapy alone or radiotherapy+chemotherapy group(n=35 patients) and a chemotherapy+radiotherapy group(n=22 patients).The treatment response,and survival data for the patients were compared between this two groups.Results:There was no significant difference in the clinical profiles between the two groups.26 patients(74%) in the radiotherapy plus chemotherapy group achieved complete response after initial treatment,whereas only 5 patients(23%) in the chemotherapy plus radiotherapy group achieved complete response.But Compared with the patients in the chemotherapy+radiotherapy group,those in the radiotherapy+chemotherapy group had a similar 5-year overall survival rate(61.9% for the radiotherapy+chemotherapy group vs.55% for the chemotherapy+radiotherapy group).Conclusions:NKTLNT do not have specific symptoms which can help for early-stage diagnosis,and radiotherapy as initial treatment can achieve better treatment response,but our research does not get an increased 5-year overall survival rate in the radiotherapy+ chemotherapy group.