Clinical study of Carbamazepine combined with Scopolamine on the treatment of refractory epilepsy

Objective It is to observe and evaluate the clinical efficacy and safety of Carbamazepine combined with scopolamine on the treatment of refractory epilepsy.Methods Open-self-matched trial with Carbamazepine combined with scopolamine as adjunctive therapy to refractory epilepsy in 51 cases,the course of treatment was 2 years.Results After treated,23 cases were effective in 51 cases,and the total effective rate was 45.1%.The cases whose patient history less than 5 years were more effective.18 cases showed mild untoward reaction as dry mouth,dizziness,debilitation,et al;1 cases showed WBC abaissement in a moment;and no cases of liver,renal function and hemogram dysfunction.Conclusion Carbamazepine combined with Scopolamine on the treatment of refractory epilepsy is effective and safe.